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So far so good. Dosage has been reduced tremendously since my liver transplant 7 months ago. I have had very few side effects and the capsules are small and easy to swallow. I started at 18 caps /day and now down to 3 /day. Be sure to follow your doctors orders and take your medicines on time. I use a Timex Datalink watch and set 2 alarms for each dose to reduce the chance of missing a dose.